FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3
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Best for
Best topical
Amazon rating
Amazon aggregate, one input among many in the Verdict Score
Based on 1 trusted source
Current price
$27.25
Updated Jun 27, 2026 · 1 min read
Sources behind this verdict
10 reviewers weighted by source trust
The consensus
What reviewers found
Synthesized across the trust-weighted source mix below.
Across the reviewers we read, Frontline Plus is the long-standing default topical, with high-trust r/dogs commenters reporting years of flea- and tick-free use and noting that buyers should ensure they get the updated Plus, Gold, or similar formulas. Retailer listings on chewy.com and petco.com describe it as a waterproof spot-on that kills adult fleas plus eggs and larvae, targeting multiple life-cycle stages over a 30-day window. The disagreement is meaningful and comes from the same high-trust source.
What reviewers liked
- Long track record with high-trust r/dogs reports of years of reliable protection
- Targets multiple flea life-cycle stages (adults, eggs, larvae) per retailer listings
- Waterproof, easy monthly application widely confirmed by verified-purchase reviewers
- Broad retail availability and predictable dosing by weight
Where it falls short
- Multiple high-trust r/dogs users report reduced efficacy in high-flea regions
- Flea shampoo and frequent swimming can undermine effectiveness
- Not a fast-acting infestation knockdown on its own
- Requires disciplined monthly reapplication
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Across the reviewers we read, Frontline Plus is the long-standing default topical, with high-trust r/dogs commenters reporting years of flea- and tick-free use and noting that buyers should ensure they get the updated Plus, Gold, or similar formulas. Retailer listings on chewy.com and petco.com describe it as a waterproof spot-on that kills adult fleas plus eggs and larvae, targeting multiple life-cycle stages over a 30-day window.
The disagreement is meaningful and comes from the same high-trust source. Several r/dogs threads report Frontline Plus stopping working in high-flea, high-tick areas, with one user speculating that flea shampoo can render it ineffective. This mirrors the resistance and washoff concerns that recur across topical reviews. The trust-weighted verdict is a dependable, widely available topical with a long track record, but one where results vary by region and reapplication habits, and where some owners eventually switch products when efficacy wanes.
- The #1 name in flea and tick protection
- Trusted by pet owners for over 20 years**
- Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application
- Protects from fleas and ticks for a full month
- Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
- Aids in the control of sarcoptic mange infestations
- Stops existing flea infestations and prevents establishment of new infestations
I had my dogs on Frontline for years and never had any issues. Just make sure you're getting the updated formulas - Frontline Plus, Gold, and ...
Yes, you can do it. For example, Just look at the dosages for Frontline Plus for S, M, L, and XL dogs. You can see that they are scaled linearly on a per/lb ...
Trust tier reflects our editorial assessment of the source, not the individual quote. Hover for the rationale. See how we tier sources →
“Frontline Plus for Dogs” · YouTube
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