K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 4-Mo Supply
Best for
Best overall (dogs)
Amazon rating
Amazon aggregate, one input among many in the Verdict Score
Based on 1 trusted source
Current price
$40.24
Updated Jun 27, 2026 · 1 min read

Sources behind this verdict
10 reviewers weighted by source trust
The consensus
What reviewers found
Synthesized across the trust-weighted source mix below.
Across the reviewers we read, K9 Advantix II is the most consistently recommended over-the-counter topical for dogs, with high-trust r/dogs threads reporting no fleas or ticks even among owners who hike frequently, and one noting they would find ticks on themselves but none on the dog. It is positioned as a five-pest topical (fleas, ticks, mosquitoes, biting flies, lice) that kills and repels rather than relying on the pest biting first, a point retailer listings on petco.com and amazon.com emphasize. Verified-purchase reviewers on walmart.com call out quick, simple application.
What reviewers liked
- Highest star average in the dog topical group (4.5 across ~48.8k reviews)
- High-trust r/dogs reviewers report reliable flea and tick prevention during outdoor and hiking use
- Repels as well as kills, covering five pest types per retailer listings
- Verified-purchase reviewers describe fast, easy application
Where it falls short
- High-trust r/dogs threads note it leaves the coat greasy
- Effectiveness can drop with swimming or flea shampoo
- Some community members prefer prescription oral preventatives for convenience
- Monthly reapplication required to maintain protection
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Across the reviewers we read, K9 Advantix II is the most consistently recommended over-the-counter topical for dogs, with high-trust r/dogs threads reporting no fleas or ticks even among owners who hike frequently, and one noting they would find ticks on themselves but none on the dog. It is positioned as a five-pest topical (fleas, ticks, mosquitoes, biting flies, lice) that kills and repels rather than relying on the pest biting first, a point retailer listings on petco.com and amazon.com emphasize. Verified-purchase reviewers on walmart.com call out quick, simple application.
The consensus is not unanimous. High-trust r/dogs commenters note the topical leaves dogs greasy and that swimming or flea shampoo can erode effectiveness, echoing a broader theme in the category that residual protection degrades with water exposure. Some community members prefer prescription oral preventatives like Simparica Trio for hands-off protection. On balance, the trust-weighted picture is of a well-rounded, repellent-first topical that earns its vet-recommended framing, with the main caveats being texture and reapplication discipline.
- K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
I've only ever used advantix. Never had any problems with my dogs getting fleas or ticks with it in use. And we like to hike. I would come back ...
Yes, sprinkled directly into the carpet. It needs to stay there to work, it cuts the exoskeleton of the fleas and they can't survive. I don't ...
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“How Effective is K9 Advantix II? Flea” · Tick & Mosquito Treatment for ...
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