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K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 4-Mo Supply

Best for

Best overall (dogs)

Amazon rating

★★★★★4.5(48,825)

Amazon aggregate, one input among many in the Verdict Score

Verdict scoreGreat
86/ 100

Based on 1 trusted source

Current price

$40.24

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Updated Jun 27, 2026 · 1 min read

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 4-Mo Supply

The consensus

What reviewers found

Synthesized across the trust-weighted source mix below.

Across the reviewers we read, K9 Advantix II is the most consistently recommended over-the-counter topical for dogs, with high-trust r/dogs threads reporting no fleas or ticks even among owners who hike frequently, and one noting they would find ticks on themselves but none on the dog. It is positioned as a five-pest topical (fleas, ticks, mosquitoes, biting flies, lice) that kills and repels rather than relying on the pest biting first, a point retailer listings on petco.com and amazon.com emphasize. Verified-purchase reviewers on walmart.com call out quick, simple application.

What reviewers liked

  • Highest star average in the dog topical group (4.5 across ~48.8k reviews)
  • High-trust r/dogs reviewers report reliable flea and tick prevention during outdoor and hiking use
  • Repels as well as kills, covering five pest types per retailer listings
  • Verified-purchase reviewers describe fast, easy application

Where it falls short

  • High-trust r/dogs threads note it leaves the coat greasy
  • Effectiveness can drop with swimming or flea shampoo
  • Some community members prefer prescription oral preventatives for convenience
  • Monthly reapplication required to maintain protection

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Across the reviews

Synthesis · not our verdict

Across the reviewers we read, K9 Advantix II is the most consistently recommended over-the-counter topical for dogs, with high-trust r/dogs threads reporting no fleas or ticks even among owners who hike frequently, and one noting they would find ticks on themselves but none on the dog. It is positioned as a five-pest topical (fleas, ticks, mosquitoes, biting flies, lice) that kills and repels rather than relying on the pest biting first, a point retailer listings on petco.com and amazon.com emphasize. Verified-purchase reviewers on walmart.com call out quick, simple application.

The consensus is not unanimous. High-trust r/dogs commenters note the topical leaves dogs greasy and that swimming or flea shampoo can erode effectiveness, echoing a broader theme in the category that residual protection degrades with water exposure. Some community members prefer prescription oral preventatives like Simparica Trio for hands-off protection. On balance, the trust-weighted picture is of a well-rounded, repellent-first topical that earns its vet-recommended framing, with the main caveats being texture and reapplication discipline.

Key specs

Source: Amazon listing
K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
Kills fleas within 12 hours of application
Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
No prescription needed

What customers say

2 verified voices
I've only ever used advantix. Never had any problems with my dogs getting fleas or ticks with it in use. And we like to hike. I would come back ...
Trustedvia r/dogs
Yes, sprinkled directly into the carpet. It needs to stay there to work, it cuts the exoskeleton of the fleas and they can't survive. I don't ...
Trustedvia r/dogs

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Video review

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How Effective is K9 Advantix II? Flea” · Tick & Mosquito Treatment for ...

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