Do vertical mice actually help with wrist pain?

The consensus across the reviewers we read is that vertical mice can meaningfully reduce wrist pronation strain for users with RSI, carpal tunnel, or general fatigue from long days at a desk. However, threads in r/MouseReview and r/logitech also flag that the relief is not universal, some long-term users report new soreness in different muscles, and there is a real adaptation period of several days to a couple of weeks.