What's the best spot treatment for cystic acne?

Honest answer from the consensus: no over-the-counter spot treatment is a reliable cystic acne fix. Specialist-subreddit threads repeatedly point readers toward a dermatologist for prescription options. That said, high-strength benzoyl peroxide gels are the most commonly cited OTC option for taking the edge off an inflamed cyst, and some reviewers report success layering them under a hydrocolloid patch overnight.